Group items tagged estrogen receptor alpha - Dr. Goodyear

Expression of aromatase, androgen and estrogen receptors in peripheral target tissues i... - 0 views

pubmedcentralcanada.ca/...PMC2891268

diabetes aromatase estrogen ER alpha ER-alpha AR

shared by Nathan Goodyear on 13 May 14 - No Cached

Nathan Goodyear on 13 May 14

Interesting animal study found that diabetic animals associated with increased aromatase expression in adrenal cortex, kidneys, and other tissue, androgen receptors were decreased in adrenal glands, and ER-alpha expression in the kidneys was increased by 159%.

<div class="cArrow"> </div><div class="cContentInner">Interesting animal study found that diabetic animals associated with increased aromatase expression in adrenal cortex, kidneys, and other tissue, androgen receptors were decreased in adrenal glands, and ER-alpha expression in the kidneys was increased by 159%.</div>

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Subtype-specific activation of estrogen recept... [Phytomedicine. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17935960

ER beta ER-beta ER alpha ER-alpha estrogen receptors ERr 731 siberian rhubarb women health menopause

shared by Nathan Goodyear on 01 Jul 14 - No Cached

Nathan Goodyear on 01 Jul 14

Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells. This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.

<div class="cArrow"> </div><div class="cContentInner">Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells. This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.</div>

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Estrogen Receptor {beta}: Switching to a New Partner and Escaping from Estrogen -- Leun... - 0 views

stke.sciencemag.org/...pe19

estrogen estradiol estrone E2 E1 ER-alpha ER-beta BPH prostate cancer inflammation apoptosis men male receptors

shared by Nathan Goodyear on 18 Sep 12 - No Cached

Nathan Goodyear on 18 Sep 12

Study shows that estradiol decreases ER beta in the prostate. ER beta is anti-inflammatory, inhibits growth, and promotes cell death: all of which would decrease risk of prostate growth and/or cancer. We know that men increase estrogen production through increased aromatase activity, which according to this study, will decrease ER beta and the prostate associated benefits.

<div class="cArrow"> </div><div class="cContentInner">Study shows that estradiol decreases ER beta in the prostate. ER beta is anti-inflammatory, inhibits growth, and promotes cell death: all of which would decrease risk of prostate growth and/or cancer. We know that men increase estrogen production through increased aromatase activity, which according to this study, will decrease ER beta and the prostate associated benefits.</div>

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Aromatase and prostate cancer. - PubMed Mobile - 0 views

www.ncbi.nlm.nih.gov/...16498360

aromatase prostate cancer male hormone hormones Testosterone estrogen estradiol ER ER alpha ER beta

shared by Nathan Goodyear on 24 Sep 13 - No Cached

Nathan Goodyear on 24 Sep 13

Study finds that aromatase activity is present in the prostate. Additionally, the balance of estrogen receptors plays a role in the interpretation of the increased estrogen production in the prostate.

<div class="cArrow"> </div><div class="cContentInner">Study finds that aromatase activity is present in the prostate. Additionally, the balance of estrogen receptors plays a role in the interpretation of the increased estrogen production in the prostate.</div>

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http://eu-acme.org/europeanurology/upload_articles/Bonkhoff.pdf - 0 views

eu-acme.org/...Bonkhoff.pdf

estrogen estradiol ER receptors ER alpha ER beta prostate cancer male men hormone hormones

shared by Nathan Goodyear on 20 Jan 14 - No Cached

Nathan Goodyear on 20 Jan 14

Estrogen plays a critical role in the initiation of carcinogenesis of prostate cancer through the ER alpha/beta expression. As the authors state in their conclusion, "...ER alpha signaling potentiates the carcinogenic effects of androgens on the prostatic epithelium."

<div class="cArrow"> </div><div class="cContentInner">Estrogen plays a critical role in the initiation of carcinogenesis of prostate cancer through the ER alpha/beta expression. As the authors state in their conclusion, "...ER alpha signaling potentiates the carcinogenic effects of androgens on the prostatic epithelium."</div>

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Expression and Subcellular Localization of Estrogen Receptors α and β in Huma... - 0 views

press.endocrine.org/...jc.2013-2017

ER ER alpha ER beta estrogen receptor fat

shared by Nathan Goodyear on 06 Jan 14 - No Cached

Nathan Goodyear on 06 Jan 14

ER alpha and ER beta expressed on fetal fat cells. The authors of this article propose that ER alpha plays the dominant in fetal adipocyte differentiation.

<div class="cArrow"> </div><div class="cContentInner">ER alpha and ER beta expressed on fetal fat cells. The authors of this article propose that ER alpha plays the dominant in fetal adipocyte differentiation.</div>

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Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.long

ER beta prostate cancer prostate cancer estrogen receptor estrogen receptor receptors hormone hormones

shared by Nathan Goodyear on 05 Feb 13 - No Cached

Nathan Goodyear on 05 Feb 13

Loss of ER-beta expression in the prostate associated with increased progression from a normal prostate to prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">Loss of ER-beta expression in the prostate associated with increased progression from a normal prostate to prostate cancer.</div>

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Loss of ERβ expression as a common step in estrogen-dependent tumor progression - 0 views

www.ncbi.nlm.nih.gov/...PMC2072930

ER beta hormones ER-beta estrogen receptor estrogen receptor beta ER alpha ER-alpha estrogen cancer tumor carcinogenesis

shared by Nathan Goodyear on 11 Sep 15 - No Cached

Nathan Goodyear on 11 Sep 15

loss of ER-beta expression is associated with increased carcinogenesis, suggesting a protective role for ER-beta against tumor proliferation.

<div class="cArrow"> </div><div class="cContentInner">loss of ER-beta expression is associated with increased carcinogenesis, suggesting a protective role for ER-beta against tumor proliferation.</div>

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Estradiol-17β Upregulates Pyruvate Kinase M2 Expression to Coactivate Estroge... - 0 views

press.endocrine.org/...jc.2013-2639

Estradiol ER alpha ER-alpha women female hormone hormones aerobic glycolysis Warburg effect estrogen

shared by Nathan Goodyear on 07 Oct 14 - No Cached

Nathan Goodyear on 07 Oct 14

This is an important study. Study found that Estradiol increased the transcription of pyruvate kinase M (PKM2)production in endometrial stromal cells. This increase in PKM2 shifted metabolism to a aerobic glycolysis pattern similar to the Warburg effect described in cancer. Additionally, increased PKM2 via Estradiol increased ER alpha transcription and functioned as a ER alpha coactivator.

<div class="cArrow"> </div><div class="cContentInner">This is an important study. Study found that Estradiol increased the transcription of pyruvate kinase M (PKM2)production in endometrial stromal cells. This increase in PKM2 shifted metabolism to a aerobic glycolysis pattern similar to the Warburg effect described in cancer. Additionally, increased PKM2 via Estradiol increased ER alpha transcription and functioned as a ER alpha coactivator.</div>

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Bisphenol A Effects on Estrogen Receptor β Expression: Implications in Prosta... - 0 views

www.niehs.nih.gov/...index.cfm

BPA bisphenol A ER-beta prostate estrogen receptors ER estrogen receptors cancer

shared by Nathan Goodyear on 21 Nov 12 - No Cached

Nathan Goodyear on 21 Nov 12

Bisphenol A downgregulates ER-beta in male prostate. This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications in prostate health.

<div class="cArrow"> </div><div class="cContentInner">Bisphenol A downgregulates ER-beta in male prostate. This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications in prostate health.</div>

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Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits es... - 0 views

www.fasebj.org/3695

resveratrol estrogen cancer breast cancer ER alpha estrogen receptor

shared by Nathan Goodyear on 20 May 13 - No Cached

Nathan Goodyear on 20 May 13

Resveratrol inhibits ER-alpha in human breast cancer cells providing potential mechanism to inhibit pro growth/pro inflammatory signaling favoring breast cancer. So maybe, a glass of red wine keeps the breast cancer doctor away??

<div class="cArrow"> </div><div class="cContentInner">Resveratrol inhibits ER-alpha in human breast cancer cells providing potential mechanism to inhibit pro growth/pro inflammatory signaling favoring breast cancer. So maybe, a glass of red wine keeps the breast cancer doctor away??</div>

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Loss of ERbeta expression as a common step in estrogen-dependent tumor progression - 0 views

erc.endocrinology-journals.org/...537.full.pdf

ER-beta ER beta estrogen cancer hormone hormones ER estrogen receptors receptor breast colon colorectal alpha ER-alpha

shared by Nathan Goodyear on 19 Nov 13 - No Cached

Nathan Goodyear on 19 Nov 13

ER beta loss has been shown to contribute to tumor progression

<div class="cArrow"> </div><div class="cContentInner">ER beta loss has been shown to contribute to tumor progression</div>

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Artemisinin selectively decreases functional levels of estrogen receptor-alpha and abla... - 0 views

www.ncbi.nlm.nih.gov/...PMC2639250

ER alpha ER-alpha estrogen receptors breast cancer artemisinin

shared by Nathan Goodyear on 27 Oct 21 - No Cached

Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Sy... - 0 views

www.jneurosci.org/...12950.full

estradiol estrogen progesterone hypothalamus receptors ER ER-alpha ER alpha hormones CNS astrocytes brain calcium channels

shared by Nathan Goodyear on 10 Mar 14 - No Cached

Nathan Goodyear on 10 Mar 14

Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model. This occurs through activation of calcium channels and influx of calcium. ER alpha appears to be the prominent ER involved.

<div class="cArrow"> </div><div class="cContentInner">Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model. This occurs through activation of calcium channels and influx of calcium. ER alpha appears to be the prominent ER involved.</div>

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Estradiol-induced proliferation of papillary and follicular thyroid cancer ce... - 0 views

www.spandidos-publications.com/...1067

thyroid papillary follicular cancer estrogen estradiol hormone hormones ER alpha ER-alpha ER beta ER-beta PR receptors progesterone

shared by Nathan Goodyear on 25 Nov 13 - No Cached

Nathan Goodyear on 25 Nov 13

Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study. What is also interesting is that estradiol did not increase PR expression.

<div class="cArrow"> </div><div class="cContentInner">Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study. What is also interesting is that estradiol did not increase PR expression.</div>

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Essential Role for Estrogen Receptor β in Stromal-Epithelial Regulation of Pr... - 0 views

endo.endojournals.org/...566.abstract

ER-alpha ER-beta BPH aromatase activity prostate men male T testosterone low estrogen

shared by Nathan Goodyear on 19 Sep 12 - No Cached

Nathan Goodyear on 19 Sep 12

ER beta agonists shown to be anti-proliferative in the prostate and "ablated preexisting prostatic epithelial hyperplasia". This has important implications: low T conditions increase ER alpha expression, which increases ER alpha production. Low T is a pro inflammatory state in men, which increases aromatase activity. Thus increase conversion of T to E2 in the stroma of the prostate results in growth. ER beta is not activated.

<div class="cArrow"> </div><div class="cContentInner">ER beta agonists shown to be anti-proliferative in the prostate and "ablated preexisting prostatic epithelial hyperplasia". This has important implications: low T conditions increase ER alpha expression, which increases ER alpha production. Low T is a pro inflammatory state in men, which increases aromatase activity. Thus increase conversion of T to E2 in the stroma of the prostate results in growth. ER beta is not activated.</div>

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SpringerPlus | Full text | Testosterone-derived estradiol production by male endotheliu... - 0 views

www.springerplus.com/...214

aromatase activity aromatase estradiol estrogen atherosclerosis hormone hormones male ER-alpha ER alpha

shared by Nathan Goodyear on 04 Oct 13 - No Cached

Nathan Goodyear on 04 Oct 13

Mouse study, but aromatase activity and ER alpha required for atherosclerosis in male mice.

<div class="cArrow"> </div><div class="cContentInner">Mouse study, but aromatase activity and ER alpha required for atherosclerosis in male mice.</div>

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Alternate Estrogen Receptors Promote Invasion of Inflammatory Breast Cancer Cells via N... - 0 views

www.ncbi.nlm.nih.gov/...PMC3266301

estrogen ER alpha ER-alpha breast cancer non-genomic signaling genomic signaling

shared by Nathan Goodyear on 11 Mar 21 - No Cached

Nathan Goodyear on 11 Mar 21

Non-genomic signaling estrogen signaling plays role in inflammatory breast cancers. Also shown in ...

<div class="cArrow"> </div><div class="cContentInner">Non-genomic signaling estrogen signaling plays role in inflammatory breast cancers. Also shown in ...</div>

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Molecular mechanisms involved in the estrogen-d... [Clin Immunol. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10779406

Lupus SLE ER estrogen receptors estrogen receptors autoimmune disease inflammation

shared by Nathan Goodyear on 31 Jul 13 - No Cached

Nathan Goodyear on 31 Jul 13

Another abstract only, but this abstract points out that ER signaling is altered in those with SLE. No discussion as to whether this was ER alpha or beta or both.

<div class="cArrow"> </div><div class="cContentInner">Another abstract only, but this abstract points out that ER signaling is altered in those with SLE. No discussion as to whether this was ER alpha or beta or both.</div>

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Breast Cancer Research | Full text | Progesterone metabolites regulate induction, growt... - 0 views

breast-cancer-research.com/...R38

breast cancer progesterone metabolite metabolites 5-alpha-pregnanediol 4-pregnene

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.

<div class="cArrow"> </div><div class="cContentInner">5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.</div>

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